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On the edge of Epigenetic Science

high performance Tet3 enzymes

Our high performance Tet3 enzymes allow the efficient oxidation of genomic 5-methyl-dC (mdC) to 5-carboxydC (cadC). We sell for research purpose only.

high performance Tet3 enzymes

Our QuGen hpTET enzymes oxidize epigenetic 5mC with extreme efficacy to 5caC. The hpTET3 double mutant stops the oxidation under our proprietary conditions at 5hmC and 5fdC. The formed 5cadC and 5hmdC can be directly SMRT long-read sequenced.

The QuGen enzymes are fully compatible with all other TET-bases sequencing technologies such as TABS-Seq. and CLEVER-Seq. By using the QuGen TET3 enzymes you will get better oxidation yields with much less enzyme and in a reduced amount of time. We offer special oxidation buffers that allow efficient oxidation of 5mC to 5caC even in non-CpG contexts for long-read non-CpG epigenetic 5mC and 5hmC sequencing.

The QuGen enzymes will be shipped on dry ice in 0.1mg or 1 mg batches with a detailed description for storage and handling. The enzymes are stable at -80°C for a year and can be kept for weeks at -20°C.

  • The invoice for customers outside Germany is shown without VAT, as the reverse charge procedure applies in this case.VAT and customs duties must be declared and paid by the service recipient.
  • Depending on country, tarifs may apply. Please consult your purchasing department and contact us in case special transport conditions are required.
  • Shipment of the material will be performed on dry ice.
  • Individual Shipping cost will be charged via checkout.
  • Delivery within 14 days

For experimental details also regarding buffer composition please consult:

H. Sahin, R. Salehi, S. Islam, M. Müller, P. Giehr, Thomas Carell Angew. Chem. Int. Ed. 2024, 10.1002/anie.202418500

Özge Simsir, Tobias Walter, Hanife Sahin, Thomas Carell and Sabine Schneider RSC Chem. Biol. 2025, 10.1039/D4CB003315B

hp-Tet3-Xenopus

Our high performance Tet3 enzymes allow the efficient oxidation of genomic 5-methyl-dC (mdC) to 5-carboxydC (cadC). The enzymes operates on single and double stranded DNA an can also oxidize 5-mC (mC) in RNA to the corresponding 5-carboxy-C (caC) RNA base.

The hpTet3DD (double mutant) is an enzyme that oxidizes 5-mdC preferentially to 5-hydroxymethyl-dC (hmdC) and 5-formyldC (fdC)

hp-Tet3-Xenopus 0,1 mg

500,00 €

hp-Tet3-Xenopus 1 mg

4500,00 €

QuGen GmbH

Herbstweg 13
82152 Krailling Germany

Phone: +49 89 86 46 64 83
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

important customer information

  • You can purchase our products in 0.1ml batches, which are individually packaged in Eppendorf tubes. Please select the required quantity. Alternatively, you can also purchase 1ml packaged in one Eppendorf tube.
  • The invoice for customers outside Germany is shown without VAT, as the reverse charge procedure applies in this case.
  • VAT and customs duties must be declared and paid by the service recipient. Depending on country, tarifs may apply.
  • Please consult your purchasing department and contact us in case special transport conditions are required.
  • Shipment of the material will be performed on dry ice and additional charged during checkout.
    • Fee Germany 50,00 €
    • Fee Europe 100,00 €
    • Fee outside Europe (US, China etc) Fee 200,00 €
  • Delivery time is approximately 14 days.
  • We sell for research purpose only.

hp-Tet3-Mouse

Our high performance Tet3 enzymes allow the efficient oxidation of genomic 5-methyl-dC (mdC) to 5-carboxydC (cadC). The enzymes operates on single and double stranded DNA an can also oxidize 5-mC (mC) in RNA to the corresponding 5-carboxy-C (caC) RNA base.

The hpTet3DD (double mutant) is an enzyme that oxidizes 5-mdC preferentially to 5-hydroxymethyl-dC (hmdC) and 5-formyldC (fdC)

hp-Tet3-Mouse 0,1 mg

500,00 €

hp-Tet3-Mouse 1 mg

4500,00 €

QuGen GmbH

Herbstweg 13
82152 Krailling Germany

Phone: +49 89 86 46 64 83
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

important customer information

  • You can purchase our products in 0.1ml batches, which are individually packaged in Eppendorf tubes. Please select the required quantity. Alternatively, you can also purchase 1ml packaged in one Eppendorf tube.
  • The invoice for customers outside Germany is shown without VAT, as the reverse charge procedure applies in this case.
  • VAT and customs duties must be declared and paid by the service recipient. Depending on country, tarifs may apply.
  • Please consult your purchasing department and contact us in case special transport conditions are required.
  • Shipment of the material will be performed on dry ice and additional charged during checkout.
    • Fee Germany 50,00 €
    • Fee Europe 100,00 €
    • Fee outside Europe (US, China etc) Fee 200,00 €
  • Delivery time is approximately 14 days.
  • We sell for research purpose only.

hp-Tet3-Vespertilio

Our high performance Tet3 enzymes allow the efficient oxidation of genomic 5-methyl-dC (mdC) to 5-carboxydC (cadC). The enzymes operates on single and double stranded DNA an can also oxidize 5-mC (mC) in RNA to the corresponding 5-carboxy-C (caC) RNA base.

The hpTet3DD (double mutant) is an enzyme that oxidizes 5-mdC preferentially to 5-hydroxymethyl-dC (hmdC) and 5-formyldC (fdC)

hp-Tet3-Vespertilio 0,1 mg

500,00 €

hp-Tet3-Vespertilio 1 mg

4500,00 €

QuGen GmbH

Herbstweg 13
82152 Krailling Germany

Phone: +49 89 86 46 64 83
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

important customer information

  • You can purchase our products in 0.1ml batches, which are individually packaged in Eppendorf tubes. Please select the required quantity. Alternatively, you can also purchase 1ml packaged in one Eppendorf tube.
  • The invoice for customers outside Germany is shown without VAT, as the reverse charge procedure applies in this case.
  • VAT and customs duties must be declared and paid by the service recipient. Depending on country, tarifs may apply.
  • Please consult your purchasing department and contact us in case special transport conditions are required.
  • Shipment of the material will be performed on dry ice and additional charged during checkout.
    • Fee Germany 50,00 €
    • Fee Europe 100,00 €
    • Fee outside Europe (US, China etc) Fee 200,00 €
  • Delivery time is approximately 14 days.
  • We sell for research purpose only.

hp-Tet3-Mouse – double mutant

Our high performance Tet3 enzymes allow the efficient oxidation of genomic 5-methyl-dC (mdC) to 5-carboxydC (cadC). The enzymes operates on single and double stranded DNA an can also oxidize 5-mC (mC) in RNA to the corresponding 5-carboxy-C (caC) RNA base.

The hpTet3DD (double mutant) is an enzyme that oxidizes 5-mdC preferentially to 5-hydroxymethyl-dC (hmdC) and 5-formyldC (fdC)

hp-Tet3-Mouse double mutant 0,1 mg

500,00 €

hp-Tet3-Mouse double mutant 1 mg

4500,00 €

QuGen GmbH

Herbstweg 13
82152 Krailling Germany

Phone: +49 89 86 46 64 83
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

important customer information

  • You can purchase our products in 0.1ml batches, which are individually packaged in Eppendorf tubes. Please select the required quantity. Alternatively, you can also purchase 1ml packaged in one Eppendorf tube.
  • The invoice for customers outside Germany is shown without VAT, as the reverse charge procedure applies in this case.
  • VAT and customs duties must be declared and paid by the service recipient. Depending on country, tarifs may apply.
  • Please consult your purchasing department and contact us in case special transport conditions are required.
  • Shipment of the material will be performed on dry ice and additional charged during checkout.
    • Fee Germany 50,00 €
    • Fee Europe 100,00 €
    • Fee outside Europe (US, China etc) Fee 200,00 €
  • Delivery time is approximately 14 days.
  • We sell for research purpose only.